Selective Precision Targeting (SPoT)

Key facts

Copied from the official Grants.gov record. Last verified October 29, 2026.

Program name

Selective Precision Targeting (SPoT)

Issuing agency

National Institutes of Health (Department of Health and Human Services)

Opportunity number

FOR-TR-27-003

Funding type

Cooperative Agreement

Funding purpose

Health

Status

Forecasted

Application deadline

Forecasted · estimated close February 17, 2026 (agency estimate)

Agency estimates

Estimated posting: December 15, 2025. Estimated award date: December 17, 2026. Estimates can change.

Published award range

Not published by the agency

Estimated total program funding

$1,500,000

Expected number of awards

5

Cost sharing or match required

No

Eligible applicants (official categories)

• State governments
• County governments
• Independent school districts
• Public and State controlled institutions of higher education
• Native American tribal governments (Federally recognized)
• Public housing authorities/Indian housing authorities
• Native American tribal organizations (other than Federally recognized tribal governments)
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• Private institutions of higher education
• For profit organizations other than small businesses
• Small businesses

Relevant to

Businesses and NonprofitsHow we determined this: Grants.gov eligibility includes small businesses or for-profit organizations. Grants.gov eligibility includes nonprofit organizations.

Geographic restrictions

None stated in structured data (federal opportunities are often nationwide). Check the eligibility details and full announcement for any limits.

Assistance Listing (CFDA)

93.350

Official source

View on Grants.gov ↗

Application URL

www.grants.gov/search-results-detail/359852 ↗Apply through Grants.gov (Workspace) using the application package on the official listing, unless the full announcement names a different submission system.

Source identifier

Grants.gov opportunity ID 359852 · Funding opportunity number FOR-TR-27-003

Posted

June 27, 2025 · Source last updated June 27, 2025

Last verified

October 29, 2026 (against Grants.gov)

Data completeness

83% of key fields published by the sourceNot published: published funding range, eligibility criteria text.

Record confidence

mediumforecast — dates and amounts are agency estimates.

Description (from the official listing)

The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by establishing a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). Targeted drug-delivery systems, including engineered nanoparticles, extracellular vesicles or focused ultrasound, are methods for delivering medications to a specific area of the body (organ, tissue, or cell) to increase the concentration of the drug in that area. Hard-to-reach locations in the body include the blood–brain barrier, central nervous system, placenta, retina, or a tumor.More specifically, the initiative goals are to:Optimize specific targeting of nanoparticle therapeutics to the target organ/cell of interestAssess biodistribution and off-target effects using a multi-organ microphysiological systemProvide evidence of functional cargo activityDetermine optimal route of administrationGrant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network.

Agency contact

Passley Hargrove-Grimes, Ph.D. National Center for Advancing Translational Sciences (NCATS)
passley.hargrove@nih.gov