Forecasted · Cooperative Agreement
Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0
National Institutes of Health, Department of Health and Human Services
Key facts
Copied from the official Grants.gov record. Last verified October 29, 2026.
- Program name
- Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0
- Issuing agency
- National Institutes of Health (Department of Health and Human Services)
- Opportunity number
- RFA-AR-26-006
- Funding type
- Cooperative Agreement
- Funding purpose
- Health
- Status
- Forecasted
- Application deadline
- Forecasted · estimated close December 1, 2026 (agency estimate)
- Agency estimates
- Estimated posting: October 1, 2026. Estimated award date: September 1, 2027. Estimates can change.
- Published award range
- Not published by the agency
- Expected number of awards
- 8
- Cost sharing or match required
- No
- Eligible applicants (official categories)
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see Additional Information on Eligibility)
- Relevant to
- Businesses and NonprofitsHow we determined this: Grants.gov eligibility includes small businesses or for-profit organizations. Grants.gov eligibility includes nonprofit organizations.
- Geographic restrictions
- None stated in structured data (federal opportunities are often nationwide). Check the eligibility details and full announcement for any limits.
- Assistance Listing (CFDA)
- 93.846
- Official source
- View on Grants.gov ↗
- Application URL
- www.grants.gov/search-results-detail/361186 ↗Apply through Grants.gov (Workspace) using the application package on the official listing, unless the full announcement names a different submission system.
- Source identifier
- Grants.gov opportunity ID 361186 · Funding opportunity number RFA-AR-26-006
- Posted
- January 22, 2026 · Source last updated January 22, 2026
- Last verified
- October 29, 2026 (against Grants.gov)
- Data completeness
- 92% of key fields published by the sourceNot published: published funding range.
- Record confidence
- mediumforecast — dates and amounts are agency estimates.
Eligibility details (from the agency)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Description (from the official listing)
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in conjunction with other NIH Institutes and Centers (ICs) as a part of the congressionally mandated NIH Helping to End Addiction Long Term (HEAL) initiative intends to publish a Notice of Funding Opportunity (NOFO) to leverage and accelerate the progress achieved in the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium.The NOFO aims to more fully refine and map the innervation of the different articular and peri-articular tissues that collectively form the joint (including bone, cartilage, synovium, joint capsule, ligament, tendon, fascia and muscle), by sensory neurons that mediate the sensation of pain.The NOFO seeks to expand initial and ongoing efforts by:Enhancing clinical pain phenotyping with multimodal profiling of new and expanded patient samples across life span and disease conditions (i.e., other musculoskeletal and/or rheumatic conditions associated with joint pain beyond knee and temporomandibular joint (TMJ)).Expanding to new preclinical and New Approach Methodologies (NAMs) in modeling joint disease.Preclinical testing of novel joint-targeted candidates identified in RE-JOIN 1.0.Focusing on peri-articular tissues in joint pain, such as vasculature, synovium, adipose, myofascial tissue, etc.Prioritizing secondary analysis of datasets and/or validation of methods and approaches in human samples.Improve data integration by developing/enhancing joint atlases that will enable integration of imaging and molecular datasets.Applications are not being solicited…
Read the full description
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in conjunction with other NIH Institutes and Centers (ICs) as a part of the congressionally mandated NIH Helping to End Addiction Long Term (HEAL) initiative intends to publish a Notice of Funding Opportunity (NOFO) to leverage and accelerate the progress achieved in the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium.The NOFO aims to more fully refine and map the innervation of the different articular and peri-articular tissues that collectively form the joint (including bone, cartilage, synovium, joint capsule, ligament, tendon, fascia and muscle), by sensory neurons that mediate the sensation of pain.The NOFO seeks to expand initial and ongoing efforts by:Enhancing clinical pain phenotyping with multimodal profiling of new and expanded patient samples across life span and disease conditions (i.e., other musculoskeletal and/or rheumatic conditions associated with joint pain beyond knee and temporomandibular joint (TMJ)).Expanding to new preclinical and New Approach Methodologies (NAMs) in modeling joint disease.Preclinical testing of novel joint-targeted candidates identified in RE-JOIN 1.0.Focusing on peri-articular tissues in joint pain, such as vasculature, synovium, adipose, myofascial tissue, etc.Prioritizing secondary analysis of datasets and/or validation of methods and approaches in human samples.Improve data integration by developing/enhancing joint atlases that will enable integration of imaging and molecular datasets.Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful multidisciplinary collaborations and responsive projects. Investigators with expertise and insights in neurobiology, pain science, data science, orthopedics, rheumatic disease, etc. are encouraged to consider applying for this NOFO.
Agency contact
National Institute of Arthritis and Musculoskeletal and Skin Diseases
NIAMS_PAIN@mail.nih.gov