Forecasted · Cooperative Agreement
HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
National Institutes of Health, Department of Health and Human Services
Key facts
Copied from the official Grants.gov record. Last verified October 29, 2026.
- Program name
- HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
- Issuing agency
- National Institutes of Health (Department of Health and Human Services)
- Opportunity number
- RFA-NS-25-031
- Funding type
- Cooperative Agreement
- Funding purpose
- Health
- Status
- Forecasted
- Application deadline
- Forecasted · estimated close January 5, 2026 (agency estimate)
- Agency estimates
- Estimated posting: October 15, 2025. Estimated award date: August 31, 2026. Estimates can change.
- Published award range
- Not published by the agency
- Cost sharing or match required
- No
- Eligible applicants (official categories)
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see Additional Information on Eligibility)
- Relevant to
- Businesses and NonprofitsHow we determined this: Grants.gov eligibility includes small businesses or for-profit organizations. Grants.gov eligibility includes nonprofit organizations.
- Geographic restrictions
- None stated in structured data (federal opportunities are often nationwide). Check the eligibility details and full announcement for any limits.
- Assistance Listing (CFDA)
- 93.853
- Official source
- View on Grants.gov ↗
- Application URL
- www.grants.gov/search-results-detail/360385 ↗Apply through Grants.gov (Workspace) using the application package on the official listing, unless the full announcement names a different submission system.
- Source identifier
- Grants.gov opportunity ID 360385 · Funding opportunity number RFA-NS-25-031
- Posted
- August 28, 2025 · Source last updated August 28, 2025
- Last verified
- October 29, 2026 (against Grants.gov)
- Data completeness
- 92% of key fields published by the sourceNot published: published funding range.
- Record confidence
- mediumforecast — dates and amounts are agency estimates.
Eligibility details (from the agency)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Description (from the official listing)
The National Institute of Neurological Disorders and Stroke (NINDS), with the National Center for Advancing Translational Sciences (NCATS), National Institute on Aging (NIA), National Institute of Dental and Craniofacial Research (NIDCR), National Center for Complementary and Integrative Health (NCCIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the conduct of large-scale, multisite clinical trials (CTs) that will inform clinicians about the efficacy or effectiveness of interventions or management strategies that reduce opioid use, improve functional outcomes and reduce pain across the continuum of acute to chronic pain associated with many types of diseases, conditions, or pain presenting as a disease itself. This NOFO will be a continuation of the HEAL Initiative Pain Management Effectiveness Research Network (ERN). The goal of this NOFO will be to expand the suite of evidence-based effective therapeutics to alleviate pain for multiple pain conditions to benefit patients and their families. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into this area of performing effectiveness trials for pain management interventions are…
Read the full description
The National Institute of Neurological Disorders and Stroke (NINDS), with the National Center for Advancing Translational Sciences (NCATS), National Institute on Aging (NIA), National Institute of Dental and Craniofacial Research (NIDCR), National Center for Complementary and Integrative Health (NCCIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the conduct of large-scale, multisite clinical trials (CTs) that will inform clinicians about the efficacy or effectiveness of interventions or management strategies that reduce opioid use, improve functional outcomes and reduce pain across the continuum of acute to chronic pain associated with many types of diseases, conditions, or pain presenting as a disease itself. This NOFO will be a continuation of the HEAL Initiative Pain Management Effectiveness Research Network (ERN). The goal of this NOFO will be to expand the suite of evidence-based effective therapeutics to alleviate pain for multiple pain conditions to benefit patients and their families. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into this area of performing effectiveness trials for pain management interventions are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in testing existing pharmaceutical, repurposed therapeutics and/or existing devices will be encouraged, and these investigators should also begin considering applying for this application.
Agency contact
Yolanda F. Vallejo, PhD
Yolanda.Vallejo.nih.gov