Forecasted · Grant
Funding Opportunity Announcement for Impact of Environmental Exposures on Gut-Brain Signaling in Neurological Conditions (R01)
National Institutes of Health, Department of Health and Human Services
Key facts
Copied from the official Grants.gov record. Last verified October 29, 2026.
- Program name
- Funding Opportunity Announcement for Impact of Environmental Exposures on Gut-Brain Signaling in Neurological Conditions (R01)
- Issuing agency
- National Institutes of Health (Department of Health and Human Services)
- Opportunity number
- TEMP-31126
- Funding type
- Grant
- Funding purpose
- Health
- Status
- Forecasted
- Application deadline
- Forecasted · estimated close January 15, 2026 (agency estimate)
- Agency estimates
- Estimated posting: October 27, 2025. Estimated award date: July 1, 2026. Estimates can change.
- Published award range
- Not published by the agency
- Estimated total program funding
- $4,000,000
- Expected number of awards
- 8
- Cost sharing or match required
- No
- Eligible applicants (official categories)
- State governments
- County governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see Additional Information on Eligibility)
- Relevant to
- Businesses and NonprofitsHow we determined this: Grants.gov eligibility includes small businesses or for-profit organizations. Grants.gov eligibility includes nonprofit organizations.
- Geographic restrictions
- None stated in structured data (federal opportunities are often nationwide). Check the eligibility details and full announcement for any limits.
- Assistance Listing (CFDA)
- 93.113
- Official source
- View on Grants.gov ↗
- Application URL
- www.grants.gov/search-results-detail/359020 ↗Apply through Grants.gov (Workspace) using the application package on the official listing, unless the full announcement names a different submission system.
- Source identifier
- Grants.gov opportunity ID 359020 · Funding opportunity number TEMP-31126
- Posted
- July 18, 2025 · Source last updated July 18, 2025
- Last verified
- October 29, 2026 (against Grants.gov)
- Data completeness
- 92% of key fields published by the sourceNot published: published funding range.
- Record confidence
- mediumforecast — dates and amounts are agency estimates.
Eligibility details (from the agency)
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Description (from the official listing)
The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research that builds on our understanding of the gut microbiome-brain axis for the purpose of identifying improved detection, prevention, and intervention strategies for environmental exposure-induced neurological diseases. Given the overlapping gut-brain signaling pathways and the prevalence of neurological conditions with gut-related comorbidities, the scope of this program would be inclusive of a wide range of neurological outcomes, including mental health disorders and chronic neurodegenerative conditions such as Parkinson’s disease and Alzheimer’s disease. The objective of this program is to develop gut-focused intervention strategies (e.g., probiotics, microbial biomarkers, nutritional supplements and novel therapeutics) to decrease risk, slow progression, or possibly reverse these neurological condition(s). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into this area of biological mechanisms underlying the effects of environmental exposures on neurological outcomes and the mediating role of the gut-brain axis are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in toxicology, microbiome, and neuroscience will be encouraged…
Read the full description
The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research that builds on our understanding of the gut microbiome-brain axis for the purpose of identifying improved detection, prevention, and intervention strategies for environmental exposure-induced neurological diseases. Given the overlapping gut-brain signaling pathways and the prevalence of neurological conditions with gut-related comorbidities, the scope of this program would be inclusive of a wide range of neurological outcomes, including mental health disorders and chronic neurodegenerative conditions such as Parkinson’s disease and Alzheimer’s disease. The objective of this program is to develop gut-focused intervention strategies (e.g., probiotics, microbial biomarkers, nutritional supplements and novel therapeutics) to decrease risk, slow progression, or possibly reverse these neurological condition(s). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into this area of biological mechanisms underlying the effects of environmental exposures on neurological outcomes and the mediating role of the gut-brain axis are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in toxicology, microbiome, and neuroscience will be encouraged and these investigators should also begin considering applying for this application.
Agency contact
Anika L. Dzierlenga, Ph.D. National Institute of Environmental Health Sciences (NIEHS)
anika.dzierlenga@nih.gov