Forecasted · Grant
Exposomic Contributions to ADRD Pathology and Resilience
National Institutes of Health, Department of Health and Human Services
Key facts
Copied from the official Grants.gov record. Last verified October 29, 2026.
- Program name
- Exposomic Contributions to ADRD Pathology and Resilience
- Issuing agency
- National Institutes of Health (Department of Health and Human Services)
- Opportunity number
- RFA-NS-26-031
- Funding type
- Grant
- Funding purpose
- Health
- Status
- Forecasted
- Application deadline
- Forecasted · estimated close October 5, 2026 (agency estimate)
- Agency estimates
- Estimated posting: July 1, 2026. Estimated award date: June 1, 2027. Estimates can change.
- Published award range
- Not published by the agency
- Cost sharing or match required
- No
- Eligible applicants (official categories)
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see Additional Information on Eligibility)
- Relevant to
- Businesses and NonprofitsHow we determined this: Grants.gov eligibility includes small businesses or for-profit organizations. Grants.gov eligibility includes nonprofit organizations.
- Geographic restrictions
- None stated in structured data (federal opportunities are often nationwide). Check the eligibility details and full announcement for any limits.
- Assistance Listing (CFDA)
- 93.853
- Official source
- View on Grants.gov ↗
- Application URL
- www.grants.gov/search-results-detail/361451 ↗Apply through Grants.gov (Workspace) using the application package on the official listing, unless the full announcement names a different submission system.
- Source identifier
- Grants.gov opportunity ID 361451 · Funding opportunity number RFA-NS-26-031
- Posted
- March 11, 2026 · Source last updated March 11, 2026
- Last verified
- October 29, 2026 (against Grants.gov)
- Data completeness
- 92% of key fields published by the sourceNot published: published funding range.
- Record confidence
- mediumforecast — dates and amounts are agency estimates.
Eligibility details (from the agency)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Description (from the official listing)
The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting research projects that investigate how specific neural exposome factors contribute mechanistically to Alzheimer’s disease-related dementias (ADRD) pathology and resilience. For the purposes of this program, exposome factors of interest include, but are not limited to, environmental toxins, sleep and circadian rhythms, stress, and the real-world conditions that modulate them (e.g., light, noise, heat).Applications will be expected to propose research on the synergistic action between multiple exposome factors, and the composite effects of mixtures of exposome factors on neural mechanisms relevant to ADRD. Applicants are encouraged to focus on mechanistic pathways (e.g., microbiome–brain interactions, neuroimmune signaling, epigenetic modifications) that link exposures to ADRD risk, progression, and resilience. Applicants are further encouraged to consider studies that cover the lifespan, including work that investigates critical or sensitive periods of exposure or factors that may lead to neurological health disparities. Applicants may propose mechanistic, translational, and/or human subjects research, drawing on clinical data, human samples, and observational or interventional studies. However, NIH-defined clinical trials will not be supported under this program.Applications are not currently being solicited. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigative teams with expertise in…
Read the full description
The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting research projects that investigate how specific neural exposome factors contribute mechanistically to Alzheimer’s disease-related dementias (ADRD) pathology and resilience. For the purposes of this program, exposome factors of interest include, but are not limited to, environmental toxins, sleep and circadian rhythms, stress, and the real-world conditions that modulate them (e.g., light, noise, heat).Applications will be expected to propose research on the synergistic action between multiple exposome factors, and the composite effects of mixtures of exposome factors on neural mechanisms relevant to ADRD. Applicants are encouraged to focus on mechanistic pathways (e.g., microbiome–brain interactions, neuroimmune signaling, epigenetic modifications) that link exposures to ADRD risk, progression, and resilience. Applicants are further encouraged to consider studies that cover the lifespan, including work that investigates critical or sensitive periods of exposure or factors that may lead to neurological health disparities. Applicants may propose mechanistic, translational, and/or human subjects research, drawing on clinical data, human samples, and observational or interventional studies. However, NIH-defined clinical trials will not be supported under this program.Applications are not currently being solicited. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigative teams with expertise in exposomics and environmental neuroscience, community engagement, ADRD mechanisms, and non-medical factors that may lead to health disparities are encouraged to apply.
Agency contact
NINDS Office of Neural Exposome and Toxicology and NINDS Office of Global Health and Health Disparities
NINDSONETOX@ninds.nih.gov